Chloroquine Syrup

1. Coacervation phase separation technique is used for

(c) Microencapsulation

2. Insulin promotes transport of glucose in which of these

(c) Muscles

3. A 54-year-old obese patient with type diabetes mellitus and a history of alcoholism probably should NOT receive Metformin because it can increase the risk of

(c) Lactic acidosis

4. Sulfonylureas act by -

(d) Increasing insulin secretion from pancreas

5. If sterilization of ciprofloxacin Infusion is achieved by autoclaving, which of the statement is correct according to I.P. -

(b) It should be sterilized at 121 to 124^{\circ}C for 15 minutes

6. With regard to the standards for sterile Water for Injection, IP, the 'residue on Evaporation' limit is -

(c) Same as that of the Water for Injection, IP

7. What should be the air velocity of laminar air flow -

(d) 100\pm20 ft/min

8. What is the official limit of total solid contents that is permitted for WFI

(c) 0.1 ppm

9. Wasserman's test is related to one of the venereal disease

(d) Syphilis

10. Antacid combinations of magnesium and aluminium salts are superior to single component preparations because

(d) All of the above

11. Heparin is the commonly used anticoagulant in cardiac surgery. All of the following are true about heparin EXCEPT

(a) Weakest acid found in living beings

12. A normal value for glucose in blood is

(d) 100-120 mg%

13. The end product of Purine metabolism in human is

(a) Uric acid

14. Gaucher's disease is characterized specially by the accumulation of -

(a) Glucocerebroside

15. Gingival hyperplasia is caused by

(b) Phenytoin

16. Which one of the following is unorganized

(b) Acacia Gum

17. Elimination after 4 half-lives in first order kinetic is.

(b) 93.7%

18. Which is known as "gunny-bag fibres"

(c) Jute

19. The IUPAC Name of Metronidazole is

(a) 1-methyl-5-nitroimidazole-2-ethanol

20. Rubreserine is a metabolic product of

(c) Physostigmine

21. Which anti-fungal agent contains piperazine ring with two 1,2,4-triazole ring in their structure

(b) Itraconazole

22. Mesna is given with cyclophosphamide to

(b) Ameliorate haemorrhagic cystitis.

23. Which of the following antitumor drugs is a pyrimidine antagonist

(b) 5-FU

24. Imipramine act by blocking the

(a) Reuptake of nor epinephrine

25. Phenobarbital is a metabolite of -

(c) Primidone

26. Slugging is

(a) Dry granulation process

27. The value of percentage deviation is 10 testing of content of tablets. It means the amount of active drug ingredient is

(b) 80 mg or less

28. Bolting is

(a) Passing the lubricant through a nylon cloth to obtain very fine particle size

29. Which Aminoglycoside cannot be used as antitubercular drug

(a) Gentamicin

30. Efavirenz limits HIV infection by

(d) Serving as an allosteric inhibitor of HIV reverse transcriptase

31. Resistance to acyclovir is most commonly due to mutation in a viral gene that encodes a protein that

(b) Phosphorylates acyclovir

32. Leucovorin is used to decrease the toxicity of

(a) Methotrexate

33. The drug imatinib acts by the inhibition of-

(a) Tyrosine kinase

34. Which of the following immunosuppressants is not used for the treatment of cancers -

(b) Cyclosporine

35. One fluid ounce is equivalent to

(b) 30ml

36. An isotonic solution is one which

(a) Does not cause haemolysis

37. Draves test' is associated with measuring the efficiency of:

(b) Wetting agents

38. Molisch reagent is chemically

(c) a-naphthol in alcohol

39. Which of the following is not a 'drug' as per the law?

(a) Empty gelatine capsule

40. Study conditions for long term stability testing of new drugs is

(a) 30^{\circ}C\pm2^{\circ}C/65\%RH\pm5\%RH

41. Fluoride content in toothpaste shall not be more than

(c) 1000 p.p.m

42. Every drug manufacturer shall maintain the Drugs and Cosmetics Rules, 1945 as per

(a) Schedule M

43. Who among the following is not a member of the Pharmacy Council of India?

(d) The Director, Central Research Institute

44. As per DPCO, every manufacturer shall submit yearly information on turnover and allocation of sales and expenses in

(b) Form IV

45. How long do the president and members of central Pharmacy council of India hold the Position

(d) 5 year

46. What is the normal glomerular filtration rate?

(a) 120ml/min

47. Which of the following material is used to determine glomerular filtration?

(a) Inulin

48. Drug bioavailability is generally in following order

(b) Parenteral > oral > rectal > topical

49. The term "displacement value" is related with the preparation of

(d) Suppository

50. "000" represents

(d) Capsule size

51. The bloom strength of capsule should be in the range of

(d) 150 to 250gm

52. Large Volume Parenteral of 1000 ml usually content?

(a) 0.9% Sodium Chloride

53. Thickness of cornea is?

(a) 0.5-1mm

54. Which of the following drugs causes bronchodilation without significant cardiac stimulation?

(b) Terbutaline

55. Indicate the sympathomimetics agent, which is combined with a local anesthetic to prolong the duration of infiltration nerve block?

(a) Epinephrine

56. Indicate the agent of choice in the emergency therapy of anaphylactic shock?

(d) Epinephrine

57. Indicate the adrenoreceptor antagonist drug, which is a rauwolfia alkaloid

(c) Reserpine

58. Hypnotic drugs are used to treat

(b) Sleep disorders

59. Which of the following hypnotics is preferred in patients with limited hepatic function?

(a) Zolpidem

60. Which of the following barbiturates is an ultra-short-acting drug?

(c) Thiopental

61. The most effective drug for stopping generalized tonic-clonic, status epilepticus in adults is

(c) Diazepam

62. The most dangerous effect of antiseizure drugs after large overdoses is

(a) Respiratory depression

63. Which of the following neurotransmitters is Involved in Parkinson's disease?

(c) Dopamine

64. Indicate the drug that induces Parkinsonian syndromes

(a) Chlorpromazine

65. Which of the following agents is an inhibitor of aldehyde dehydrogenase?

(c) Disulfiram

66. The drug which decreases craving for alcohol or "high" pleasurable effect that comes with renewed drinking is

(c) Naltrexone

67. The combination of disulfiram and ethanol leads to accumulation of

(d) Acetaldehyde

68. Which of the following agents may be used as an antidote for ethylene glycol and methanol poisoning?

(b) Fomepizole

69. Narcotics analgesics should

(a) Relieve severe pain

70. Which of the following opioid analgesics is used in obstetric labor?

(c) Meperidine

71. Which of the following opioid analgesics is used in the treatment of acute pulmonary edema

(a) Morphine

72. Which of the following non-narcotic agents is salicylic acid derivative?

(c) Aspirin

73. Indicate the non-narcotic analgesic, which lacks an anti-inflammatory effect

(b) Paracetamol

74. Neuroleptics are used to treat

(b) Psychosis

75. Parkinsonian symptoms and tardive dyskinesia are caused by blockade dopamine in

(a) The nigrostriatal system